6.02.2011

Saying Goodbye to Dr David Colman

http://www.montrealgazette.com/health/Visionary+leader+neuroscience/4878315/story.html

posted by Maria Schamis Turner @ 6:05 PM   0 Comments

4.24.2011

At McGill

I will be speaking at the Science Career Panel at McGill University on Tuesday April 26th.

Science Careers Outside Academia
April 26, 12:00 - 1:30

If you think that a graduate degree in science means a future only in academia, come discover what scientists are doing in the private and public sectors and how they partner with academics. A collection of seasoned professionals will discuss how they capitalized on their graduate training in the Sciences, brainstorm about your career options and answer any questions you may have about the industry at large.

PANELISTS:
Maria Schamis Turner, Freelance Science Writer
Janine Lepage, Senior Consultant, Le Groupe JBL
Bill O'Neil, Associate Director, Business Development, BioMedCom
Anne-Marie Alarco, Director of Research Development, Génome Québec

For more information: http://bit.ly/hTWcmY

posted by Maria Schamis Turner @ 2:26 PM   1 Comments

3.14.2011

People behaving badly: An interview with Alain Dagher about addiction, obesity, and making bad decisions

Alain Dagher is a neurologist who specializes in movement disorders and functional brain imaging. He became interested in dopamine through his work in Parkinson’s, and began to study things like addiction and other dopamine-related problems.

You do research in the field of addiction and obesity. What are you looking at specifically in this field?

We’re basically trying to understand addictive phenomena, where an individual loses control of their behaviour. It has something to do with how we make decisions or fail to make decisions. We’re interested in understanding what brain regions are implicated in addiction and what they do specifically. What dysfunction leads to drug craving or the inability to resist smoking when you’re trying to quit? With respect to appetite, the basic idea is that brain regions involved in controlling of appetite are the same regions involved in addiction. That’s why addictive drugs are addictive, because they act on those structures.

The dopamine reward centre?

Dopamine plays a big role in it – it’s the main determinant of reward learning and motivation to obtain rewards. We’re doing a lot of research trying to measure vulnerability to addiction, why some people become addicted and others don’t. It’s partly genetic, partly environmental, and part of our research is aimed at looking for those things in the brain that predict that vulnerability.

What kind of studies are you doing?

We often do studies in healthy subjects to try and see decision making related to rewards and/or reward learning, that is, how you learn that something is rewarding, what parts of the brain are involved in that learning process, and how dopamine affects that process. That is one kind of research.

We’re looking also at the role of hunger signals, signals from the gut and from the rest of the body that act on the brain to change appetite. The reason you are hungry before lunch, for example, is that a bunch of hormones in the blood change their levels. The satiety hormone levels go down, and the hunger hormones, there is only one hunger hormone called ghrelin, it goes up. These hormones, which are secreted by the gut and by fat cells, and by the liver and pancreas, all act on the brain to make you desire food and make you willing to expend energy in order to obtain that food. And this is very interesting because we think that these hormones play a role in obesity – at the very least they play a role in the inability to lose weight. When you go on a diet you decrease caloric intake and the first thing that happens is you get hungrier. That, in part, is because of these hormonal signals that detect the reduction in caloric intake and tell the brain: “Hey something is going wrong, you’ve got to eat more.” Obviously this is of great interest in the treatment of obesity and diabetes, which is now the number one cause of disease in the Western world.

When we make a decision to eat a donut even though we’ve had a full meal - do these hormones play a role in that?

That’s what we’re trying to study. We’re trying to understand how ghrelin acts on the brain, how it’s involved in hunger, in making foods more rewarding, and in how we learn about food. One aspect of obesity in children is that being exposed to high calorie food, especially very sweet soft drinks, seems to create a process of conditioning, just like Pavlovian conditioning, where the reward value of the sweet food becomes higher and higher. Once that’s happened, it’s there for life, so we’re trying to study that process of conditioning to foods.

There’s also an interaction between these hunger hormones and stress, a complex interaction. Stress can enhance the activity of hunger hormones, and vice-versa, some of the hunger hormones can actually cause stress, at least I think they can. So, stress is also a major factor in weight gain and obesity.

We’re also looking at this from a standpoint of what’s called “neuroeconomics.” It’s clear that a major cause of the increase in obesity in the last 30 years is cheap food. The cost of food has gone way down, especially the cost of calories. When food is cheaper people eat more. There’s also a lot of evidence that obesity is becoming a disease of the poor. In this generation there’s a very weak association between socioeconomic status and body mass, but in children there’s a very strong association. In the next 20 to 30 years obesity is going to become a disease of the poor in the Western world, much like cigarette smoking. Even in the developing world, they’re going from famine to obesity in one generation. China, for example, is leading the world in the increased incidence of diabetes. Studying neuroeconomics, that is bringing in financial decision-making aspects to the research, we think is potentially very helpful.

We weren’t programmed to deal with abundance.

Well, presumably not. Abundance is something that we detect, but normally abundance is followed by winter, that is by lack of food. When food is abundant you eat more, when it is scarce, you save your energy. Now we’re in a situation where it’s always abundant.

How do you factor in neuroeconomics?

You can look at it in a simple way: how do hunger hormones change your willingness to pay money for food? In animals what that means is if an animal is very hungry, it may be willing to work harder for food. It may be willing to take more risks, to spend more time in the open, to risk being at the mercy of predators for example. Or, if you are a predator, you may be more willing to go and attack a large animal at risk to yourself. Not surprisingly, people are willing to pay more for food when they are hungry than when they are full. The brain systems that are involved with changing your degree of motivation to eat are also implicated in your degree of motivation to pay for food. By bringing in these neuroeconomic approaches, you can formally study these things using paradigms that have been used by economists for 40 – 50 years.

Obesity is also related to other aspects of decision-making; there’s some evidence that people who are overweight are more likely to be impulsive, that is, to make rapid decisions without due consideration of the consequences. They’re also more likely show what’s called “delayed discounting,” that is, they discount the value of future rewards. For example, if you offer someone $100 now, or $120 a month from now, they’ll take the $100 now, because the $120 is discounted, it’s worth less when it’s in the future. This delayed discounting goes along with impulsivity and the desire to have the immediate reward. It’s measured by financial paradigms but it’s actually associated with obesity. It’s a small association, but it’s there.

How does this understanding translate into treating problems like obesity?

If you understand how peptide hormones in the gut, or stress, or various patterns of decision-making can impact obesity, you can develop therapeutic approaches. For example, you might conclude that you shouldn’t go to the supermarket when you’re hungry—people know that already. You would also conclude that maybe you shouldn’t skip meals because if you skip meals your appetite hormones will be greater and you’ll eat more at the next meal, for example. That’s at the individual level. You might also use that research to develop drugs to reduce appetite or to test potential drugs. At the societal level, you could also [use the research] to make policy recommendations. You may not need the neuroscience to say that we should not subsidize unhealthy food, but the neuroscience helps to promote that idea and maybe to inform what kinds of policies we should be taking to reduce obesity in the general population. So there are two different approaches, the treatment of the individual person and the treatment of society, both of which I think will benefit from the neuroscience.

There’s no weight loss clinic in Quebec that’s funded by the government. It’s the thing that costs healthcare systems the most, and nothing’s done about it. Now, the success rate of weight loss programs is extremely low. Weight Watchers has the highest success rate and it’s about 1%.

What about drug treatments?

As for drugs for weight loss, the situation is not so good right now. There was one drug called rimonabant that was very effective but it caused mood side effects, it caused depression. It was taken off the market, and that has scared all the drug companies I think. The problem, of course, is if the drug acts on the reward system it risks having serious side effects. If you suppress the function of the reward system chances are you will cause depression or mood problems in most people. So one of the problems is to find a drug treatment that will not cause these side effects. Although if someone has diabetes and obesity, it’s going to kill them, so it’s worth risking depression, especially if you follow the patient and you monitor their mood. If they have problems you take them off the medication.

There’s a drug called bupropion that helps for quitting smoking but is also useful for weight loss. I think there’s a company that has a phase-3 trial with a bupropion plus something else. Again, it will have side effects but it might be acceptable to risk the side effects when you have obesity and diabetes.

Currently the only treatment for obesity that works is bariatric surgery, which is obviously reserved for very overweight people, morbidly obese people.

How does the surgery work? Does it affect ghrelin levels?

We don’t know. Some of the surgeries do appear to reduce ghrelin levels. Basically all of these surgeries restrict the stomach in some way, either by restricting the size, or removing part of the stomach. They have multiple effects and it is still not known how they work. Some effects clearly have to do with decreased food intake; you eat less because you feel full sooner. But there are other effects, for example, on the first day after the surgery, diabetes is cured. That can’t be due to weight loss, of course. It’s quite puzzling.

In terms of understanding impulsivity, what is considered normal?

There’s not necessarily a “normal,” but you can develop laboratory tests of impulsivity (there are several) and come up with average patterns of behaviour. You can decide that something is normal if it falls one or two standard deviations away from the average pattern, that’s the usual way we define normality in biology. A lot of the associations are weak, but there’s a very strong association between attention deficit disorder and obesity, for example. Attention deficit is a proto-type disease of impulsivity. It’s an inability to focus attention correctly, so things that grab your attention are hard to resist. It’s not attention deficit so much as an inability to properly regulate attention, and so people with ADHD tend to be very impulsive and have a much higher rate of obesity than people who don’t have ADHD. They also have a higher rate of addiction. And there are other diseases that predispose to obesity: depression, anxiety disorders, schizophrenia, almost any mental health disorder predisposes to obesity.

Why is that?

We don’t know. That’s one of the things we are studying. The study of the brain’s role in obesity is extremely new.

In terms of addictions, are you also looking at people who are addicted to gambling, drugs, etc?

I’ve done a couple of studies on gambling. And also a lot of studies on cigarette smoking, That’s the main drug that I have studied.

As an ex-smoker, it seems to me that the addiction never really goes away. I’ve quit, but I don’t feel as if I have unlearned the addiction, more as if I overruled it somehow.

That’s because the learning process has been hard wired. That’s what an addiction is, an aberrant learning process, where you learn to value the drug. We know that it involves the same brain areas that are involved in the control of eating. So just like eating is an extremely important behaviour, when a drug comes into that system, it sort of subverts the system into making your brain think that smoking is crucial to your survival. That’s one way to think about it. And some people can’t overrule it, and that relates back to this impulsivity issue. The more impulsive you are, the more likely it is that you can’t resist those urges.

Researchers in Robert Zatorre’s lab have shown that music can affect the dopamine system. Does this mean that we can become addicted to music?

No one has ever described music addiction, as far as I know. Usually an addictive behaviour has to be harmful, it’s very hard to see how listening to music could be harmful. I don’t know of any cases of people who listen to music at the expense of social activities—that’s one way behavioural addictions are defined. You don’t talk to your spouse or you don’t have friends because you spend all your time on the Internet, say. I’ve never heard of anything like this for music.

Behavioural addictions are difficult – the problem is that you spend too much time doing one thing and less time doing other things that you should be doing. That may not be enough, I think, to call something an addiction. For example, if a child would rather play video games than do their homework, you would not really call that an addiction, that would be silly.

Why is it that one thing that triggers the dopamine system might go into overdrive and another thing, like music, doesn’t?

The dopamine system is somewhat self-regulated but drugs act directly on the brain cells that release dopamine, and so they bypass any regulatory system. That’s always been the theory of why drugs can be addictive. Why gambling is addictive, I think is really not clear, although it’s clear that it is. In fact it’s probably one of the worse addictions you can have. It’s extremely damaging.

[This interview has been edited for clarity.]

posted by Maria Schamis Turner @ 3:34 PM   0 Comments

3.01.2011

A short story by neurologist Liam Durcan

At First it Feels Like Hunger

Elaine’s brother Dennis arrives with his girlfriend that Friday evening, the headlights of the car tunneling through a crystal-cold night and stopping near the house at a little past ten. Elaine and her mother have stayed up to meet them, as it’s the first time he’s brought Sarah home. Sarah. Elaine loved the name from the moment Dennis told them about her. In the days leading up to their arrival it was all she could think about; she repeated the name over and over to herself and imagined a woman of intelligence and beauty, a figure sitting alone in a garden, aristocratic features heightened in the evening light.

Elaine presses her head to the window to get a closer look at the car that now sits quiet and dark in the drive, the whole scene obscured by her breath that pulses on the pane in front of her. She wipes the window clean with the heel of her hand and is able to make out a light coming on in the car as a door is opened. The motion of her hand on the window produces a delicate honk that causes her mother to look up from the kitchen table.

Read the rest of the story on carte blanche.

posted by Maria Schamis Turner @ 7:06 PM   0 Comments

1.27.2011

On Narrative and Neurology: A conversation with Liam Durcan

Liam Durcan is the Neurologist-in-Chief at the Montreal Neurological Hospital and Clinical Director of Neurology at the McGill University Health Centre. He is also the author of the novel Garcia’s Heart and a book of short stories, A Short Journey by Car.

I asked Durcan about the relationship between narrative and neurology. Here is part of the wide-ranging conversation that followed.

Liam Durcan - I guess I approach it in a few different ways. As a neurologist I am interested in the generation of narrative, that is, in the neurobiological mechanisms—the language areas plus the emotional part of the brain plus the frontal lobes—that together generate some sort of sequential order out of things. I find that just fascinating in terms of narratives and disordered narratives that we see in neurology. For example, you can have perfect language function and good recall but if your frontal lobes aren’t working, it is sometimes quite difficult to be able to relay history in an organized way. You see that in some patients with frontal temporal lobe dementia.

Also, as a physician the way into any problem is through narrative. You realize fairly early on that you are in the process of translation: translation of the patient’s experience into their history. There can be multiple parallel histories and then you translate that into the history for the medical record, history that you will base investigations, diagnosis, and prognosis on. I think you gain either an explicit or implicit reverence for narrative. Some people have said that it’s on the wane, that we are relying more on technology. There’s a joke that the only question you really have to ask people now is “Do you have any metal in your body?” because you need to ask that before you get into an MR. I can understand that but it’s not just about having the tools but appropriately using them. Not only is narrative important to become an effective clinician in terms of getting the right diagnosis and applying medical technology properly, but I also think it’s probably a key step in the development of empathy.

MST - It strikes me that narrative is probably still more important in neurology than it is perhaps in other medical fields.

Yes, simply because the complaints can be so complicated or protean or vague. Psychiatry relies on narrative even more but we rely on it a great deal. That being said, it’s always interesting, especially in a hospital, to understand how the narrative can be split. One of the things you’ll notice if you see a patient waiting for a test and they’re away from their ward, is that they cannot help but look in their chart. And that’s because they understand that their narrative and the narrative about them are not necessarily the same. And they want to know all the discrepancies. And they have the right to know. I always feel like asking, “Were you surprised? Shocked? Disappointed?”

Rita Charon at Columbia has done pilot projects where she’s had patients keep their own chart, a parallel chart, to see what the major differences were. Sometimes I’ll come out of a patient’s room with the team, and I’ll think, “that went well,” and then I realize through conversations with the nurses, or with the family, that the patient understood nothing. Or misinterpreted or felt that the explanations were brief, or too complicated, or lacked any sort of emotional content. You see all these discrepancies. I think that’s true of any form of communication but when health issues are involved it’s heightened. Especially when there are neurological issues and the ability to understand what’s going on might be impaired somewhat.

Is there anything that you do to try and help the patient construct the narrative about their illness?

You ask them what they think is going on. You can be frank. One of the questions I tend to ask most at the bedside, or in the office is: “What are you most afraid of?” Is it a disease that you have read about on the Internet? Is it independent of disease but the fear that you might need a wheelchair and that would mean you’d have to move out of your house? Is it your relationship with your spouse or how you’ll be seen in the eyes of your children? Do we need to get the children in and speak about it? Sometimes when I’m seeing patients for the first time, and they’ve had sort of a long course, I’ll ask, “What do you understand about what’s going on?” It gives you insight into their level of understanding. Sometimes patients won’t play every card, but it gives you some insight into their ability to understand the narrative that has been constructed around them, and the differences between that and the narrative they’ve constructed for themselves.

What’s the longest you’ll see or follow a patient for?

Usually a consultation is 45 minutes. I’d like to take longer but with things like waiting lists, doctors calling you to see cases… Typically we’ll talk about things in a preliminary way. Sometimes patients do need rapid referral. For example, if the patient has a bad disc in his back, and it’s been there for six months and it’s not getting any better, you might have to refer him to a surgeon. We had a patient in this office once who was telling me (and he was very descriptive about things), he said, “I’ve got this terrible chest pain.” I was with a resident, and I wanted to show the resident that when the patient says certain things, you just have take him at face value. So I walked him across the street to the emergency room. I didn’t actually think he had anything wrong with his heart, but it turned out he was having a heart attack.

Other times, you don’t know what’s going on. You need to find out what the patient’s concerns are, you express your own concerns, and propose some tests to try and understand them. In our system you wait a bit longer for some tests, things like imaging, so you try and give the patient some reassurance that if there is any change, that you’ll see them again. We’ve forgotten the value of the follow up appointment. Visits to the doctor are too often like visits to the accountant, they’re sort of yearly reckonings. But sometimes there are issues that come up and being able to see the patient allays your own fears. And I often find just talking to the patient on the phone can allay their fears.

In terms of follow up, it depends. Some patients I’ll see every two months, others need to be seen every couple of years, depending on the disease process and on the patient’s level of anxiety. I’ll see patients who don’t have a neurological diagnosis but they feel that their muscles are jumping and they are sure they have Lou Gehrig’s disease. You try and reassure them but you know that they have this tremendous anxiety. What you say is “I’ll see you every few months and reassure you,” and as the disease doesn’t progress you try and reinforce that. Most patients after two or three visits don’t need to be seen anymore. If you see them once and say, “It isn’t Lou Gehrig’s bye bye,” they’re just going to see doctor after doctor. I think the value of the follow up is extremely important. Also they trust you if they see you a few times. And sometimes what you thought was not neurologic turns out to be neurologic, so I think it’s a tremendous benefit.

Is that because some of the manifestations can vary so greatly?

Some illnesses are variable by definition. For example, myasthenia gravis can be bad at certain times of the day. Or sometimes the symptoms that the patient feels might be quite pronounced, but you just can’t see objective evidence of it and it might take two to three months to declare itself. It’s the old saying, sometimes you only know you’re in the pumpkin patch in the fall.

Personal accounts of illness that I’ve read seem to focus a lot on identity. Patients are reconstructing their personal narratives to accommodate for their illness.

Absolutely. When we talk about narrative, every person carries three or four. There’s the autobiography, the grand history of yourself, then there’s that moment-to-moment narrative that we’re all judging ourselves upon, and then there’s the narratives that are constructed about you. I find that interesting.

As a physician do you feel that it’s part of your job to help the patient readjust his narrative?

I think you have to be careful, because you can readjust it in a way that just suits yourself. In other words, if I need to get you out of the office because I’m behind and have a full waiting room, I have to ask myself “Am I doing things for those reasons?” You always have to be vigilant about what you’re doing in terms of changing the narrative. Also, the narrative has meaning for more than just the patient. They don’t teach you this in medical school, but there are third parties who are very interested in the patient’s narratives. If you’re filling out Régie des rentes forms or insurance forms for somebody, you have the legal responsibility to be truthful, but sometimes those two narratives come into conflict. I’ve inherited patients who have been given diagnoses have been revised, and I am sure I have given diagnoses that in five to ten years might be revised. That can have a really major impact, not just on the person’s finances, but also on the person’s identity. If you’ve been told you’re not going to get better, you will often attain a sort of sick role, you’ll say I can’t do certain things, I shouldn’t expect to do certain things, and you’ll curtail certain thoughts about what you’re going to do in the next five years. It’s really important to consider that the narrative is not just what’s come before but also the projected narrative into the future. We don’t talk a lot about prognosis but people are constructing their own narratives years in advance as.

Why don’t you talk a lot about prognosis?

Well, I think that we’re not as good at talking about it as we are about diagnosis. If you look at medical charts, the diagnosis has to be mentioned, it’s a medical necessity, but not the prognosis. I’m on the wards right now, and I like to talk about prognosis with people, but I’m sure I’ve probably not had as explicit a discussion as I should have with most patients. What’s the risk of this person having another stroke and was it explained to him? What’s the risk of this person’s multiple sclerosis getting worse in the next five years? I mean, there is an element of uncertainty, and we don’t like to expose ourselves to uncertainty. And sometimes patients aren’t prepared for that, especially when they are in a hospital bed. But in all cases prognosis should be discussed.

What kind of people do you think go into neurology? Is there a personality type?

In medical school they talk about the different personality types that are drawn toward different specialties, e.g., the surgeon is a decisive person. They use to describe neurologists as being bridge players that were interested in sophisticated systems and arcane information—I always found that offensive. It was a way of saying that you were interested in things that have really no applicability to patients’ lives. I think that was insulting to the neurologists of fifty years ago, who were really palliative care physicians. These weren’t cold diagnosticians who walked away; they were people who looked after people.

I don’t know that there’s any clear type. I think you have to have curiosity, but then I think curiosity is important for any sort of endeavor. When we bring people into our program to train them, at the end of medical school, one of the questions we ask is, “How do you feel about most of your patients not getting better? Are you able to deal with that?” That can be tough. We do have people when they see patients getting worse and worse that will view that as some sort of repudiation of their efforts, as some sort of ego destroying event. But I think if you take a larger view of medicine, most of what we do is palliative, aside from treating a few infections and taking out the rare inflamed appendix. We’re moving curves, we’re delaying events, and we’re trying to prevent things. And I think once you understand that, you have a deeper understanding of medicine, the pursuit of neurology doesn’t seem full of despair.

When did you start writing?

I’ve written since my teenage years and then I put it away for medical school. I finished my residency when I was 28 years old. I was a qualified neurologist but I felt grossly unprepared in some larger sense to look after people. I felt like I needed more of a liberal arts education at that point in my life. And I think that I probably began writing for that reason, to try and address some of that. I think part of it was also emulation—I love reading and I love well-written prose, it gives me a tremendous amount of pleasure.

How do you find the time to write?

It was easier before. I would get up at four in the morning and write for an hour and a half. After the second child, it was a bit more difficult. Thomas, our youngest, was born in 2008, and there was just less and less time. Also, I have just taken on a few more administrative duties in the last couple of months that have made any sort of pretence at writing more difficult. I used to think that having a limited amount of time to write was conducive to writing and I still do. I deal better when I have constraints than when I have absolute freedom. If I had a week off, I don’t think I would write, but if I had 30 minutes a day, then I would. I remember commuting and writing on the suburban commuter trains. I found that really concentrated my writing. And I found that the individual plot issues or story issues that I was concerned about would seem to have been addressed in the time when I wasn’t thinking about it and I was interested in that. It seemed to work for me. I published a fair bit in a few years. When I wrote a book, I think I had been thinking about it for a long time, because it didn’t take that long to work the book into shape. It was almost a bit embarrassing—it just seemed to happen fairly naturally.

Why did you choose to make the main character of Garcia’s Heart a neuroscientist?

When I started writing, I thought there is no way I want to write medical narratives. I thought if I write, I just want to be a writer, I don’t want to be labeled as the doctor/writer. I wanted people to read the book and be refreshed that it wasn’t a narrative in a hospital. The one lament I had about the book is that I couldn’t make it work any other way. I really hesitated at every step. The story didn’t start with a person interested in neuroscience, it started out as a short story about a person who works in a Dépanneur, for someone who used to be a doctor. (It was originally set in the 1980’s, with a Vietnamese doctor.) As it got bigger and bigger, I realized that he would have to identify with him in a professional way, so he had to be a doctor too. Then as I was writing, I was thinking about theories of moral responsibility and who can best understand these ideas on an intellectual level and yet be baffled on an emotional level, and I ended making the character essentially a neuroscientist. I didn’t want to write it that way, but I couldn’t see any way out of it. So I ended up writing a narrative about a disaffected doctor who wasn’t practicing medicine. That was the saving grace.

But it’s interesting, especially for those of us who aren’t neuroscientists. One of the things that struck me was the way Patrick sees things, how he sees the world through the lens of neuroscience. Is that partly how you see things?

Well, no. I think that’s the bias that we have in medicine and in neurology. We’re necessarily materialistic and reductionist. We deal with understanding function through dysfunction, which pushes us in that direction. That being said, I wanted the character to have very sophisticated technical and material understanding and yet be completely baffled emotionally. I mean he was not only baffled, he was miserable at his inability to figure things out. I wanted to make that point, that things have to be understood not just at an intellectual level but also at an intuitive level.

He comes across as a stereotypical scientist – he knows a lot about the world but doesn’t know why his relationships failed.

Or how to think about this person. I think that’s perhaps that’s how I felt when I finished my training, and I was trained by very humane people and in a curriculum that I don’t think meant to produce a person who felt the way I did. But I just felt that I was missing something. By the end Patrick comes towards that understanding, and I think he’s more satisfied in certain ways. Not to say that I think I have achieved that—I think it’s always a process, a continuing process.

We know more about the brain than we used to and there is starting to be a cultural resonance of what’s happening in neuroscience and medicine…

I think there have been huge cultural changes in terms of the acceptance of neuroscience or the understanding that the principles of neuroscience and neurobiology can be very interesting and can, not replace, but complement things like psychology. I also view neuroscience as being at that point that genetics was 15 years ago, when they said, “This is going to explain everything.” We do the genome: we’ve got the answer. That simply hasn’t been… it’s just more complicated than that. That hasn’t lessened the importance of genetics it’s just that we have a more nuanced and sophisticated understanding of it. And I think you’re seeing the same thing now in neuroscience. We’re going through a phase of “neurocracy” and the skeptical backlash against it, which I think is healthy. There’s been a great deal of wariness about how to apply what we know about neuroscience to our concepts of law or public policy, and I think people are beginning to understand that it can’t define things but it can complement our understanding.

[This interview has been condensed and edited for clarity.]

posted by Maria Schamis Turner @ 7:03 PM   2 Comments

1.05.2011

A Neuro Christmas

Dr Ken Hastings doesn’t look much like Santa Claus, but he shares a few of his more important traits: he has a beard, he is jolly, and he brings joy to others at Christmas. He is, in fact, much slimmer than Santa and he has a very different day job. Hastings works as a researcher in the neuromuscular research unit at the Neuro. Hastings’ passion, next to understanding the molecular biology of muscle cells, is music. “I’m an amateur musician,” says Hastings. “I don’t have any training, but I just love music.” His love of music led the researcher to join the Neuro Cosgrove Choir (named after its founder, Dr Bert Cosgrove) some 25 years ago. “I still remember the first practice I had,” says Hastings. “The choir director said: ‘We’ll sing, “Deck the Halls,” and you’ll be a tenor.’ When it came time to sing, I sang the melody that everybody knows. He said: ‘No, no, no, no! Each voice has a different part. You have to learn your part.’ That’s how I learned about harmonizing.”

Hastings learned how to harmonize so well that 12 years ago he took over as choir director. Every Christmas he gathers together a group of fellow researchers, technicians, students, doctors, neuro-psychologists, and pathologists to practice a small repertoire of carols that they perform at the Neuro’s Reitman lunch (an annual Christmas lunch for the whole staff, given by the Reitman family) and on the wards at the Royal Victoria Hospital and the Neuro.

This past year’s iteration of the Choir got together on a Monday evening before the holidays to share some food and a glass of wine before making their way around the wards. The mood was cheerful with a slight touch of pre-performance jitters. There were those, like Janet Arts, who had been singing with the choir since 1975, one year after it was founded, and who had only missed one year of caroling in over 30 years, and others who were singing with the choir for the first time. There were no obvious correlations between occupation and participation, except for the two students from the music and neurosciences lab, and an unexplained strong showing from the transcranial magnetic stimulation lab at the Royal Vic.

After the food and a little bit of singing to warm everybody up, Hastings gathered his guitar, a green Santa hat, and his carolers and went to find some patients to sing for. Outside the Intensive Care Unit at the Neuro, he reminded the group that they needed to keep the volume down for the ICU patients. Once inside, he gathered the choir behind him in the hallway, just outside a patient’s room. Wedged in next to shelves of supplies, the group looked expectantly towards their leader. Hastings sounded a note, nodded, and they broke into a hushed version of “Silent Night.” In the quiet of the ward, the song filled the hallway. A face peeked around a pulled bedside curtain. The nurses listened but continued to go about their business. It was only when Rosalind Sham, a second-year neuroscience student at McGill, started to sing a solo of “Have Yourself a Merry Little Christmas,” that all activity seemed to stop. Something in her voice lent a sacred tone to the song. As the singers made their way around the ward, several had tears in their eyes.

A couple of floors down, rousing versions of “The Virgin Mary Had a Baby Boy” and a Hanukkah song had the nurses dancing. “How do I join the choir?” one asked. In the epilepsy ward, patients and visitors applauded. “They sing well,” said someone, approvingly. On yet another ward, a young woman pulled out her phone and filmed a short video of the singers. “Will we be on youtube?” one of the carolers asked. “It depends how good you are!” joked the videographer. As the evening came to an end, Hastings thanked the Choir. “It was a very good year,” he said.

posted by Maria Schamis Turner @ 7:50 PM   0 Comments

12.24.2010

Review: The Mind's Eye, by Oliver Sacks

For those of us whose vision is relatively unimpaired, the world appears a coherent place. We see words on a page or the face of a loved one sitting across the table from us and can easily recognize both as what they are. This is enabled by complex visual circuitry in the brain, which is divided into discrete areas, each responsible for “seeing” different things. There are groups of neurons that specialize in faces, others in words, and yet others that are responsible for detecting movement. The brain then combines these different pieces together (just how is not fully understood) to form a coherent whole.


Read more on the National Post website

posted by Maria Schamis Turner @ 10:39 AM   0 Comments